Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients.

Abstract

RATIONALE Aspiration of infective subglottic secretions causes ventilator-associated pneumonia (VAP) in mechanically ventilated patients. Mechanisms underlying subglottic colonization in critical illness have not been defined, limiting strategies for targeted prevention of VAP. OBJECTIVES To characterize subglottic host defense dysfunction in mechanically… (More)
DOI: 10.1164/rccm.201709-1819OC

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