Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

@article{Thien2004ExcessBR,
  title={Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.},
  author={Marilyn Thien and Tri Giang Phan and Sandra Gardam and Michelle Amesbury and Antony Basten and Fabienne Mackay and Robert Brink},
  journal={Immunity},
  year={2004},
  volume={20 6},
  pages={
          785-98
        }
}
The role of BAFF in B cell self tolerance was examined by tracking the fate of anti-HEL self-reactive B cells in BAFF transgenic mice using four different models of self-reactive B cell deletion. BAFF overexpression did not affect the development of self-reactive B cells normally deleted in the bone marrow or during the early stages of peripheral development. By contrast, self-reactive B cells normally deleted around the late T2 stage of peripheral development were rescued from deletion… CONTINUE READING
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