Excess Aldosterone under Normal Salt Diet Induces Cardiac Hypertrophy and Infiltration via Oxidative Stress

@article{Yoshida2005ExcessAU,
  title={Excess Aldosterone under Normal Salt Diet Induces Cardiac Hypertrophy and Infiltration via Oxidative Stress},
  author={Kaoru Yoshida and Shokei Kim-Mitsuyama and Ryotaro Wake and Yasuhiro Izumiya and Yasukatsu Izumi and Tokihito Yukimura and Makiko Ueda and Minoru Yoshiyama and Hiroshi Iwao},
  journal={Hypertension Research},
  year={2005},
  volume={28},
  pages={447-455}
}
Aldosterone is known to play a role in the pathophysiology of some cardiovascular diseases. However, previous studies on aldosterone infusion have been mostly performed in animals receiving sodium loading and uninephrectomy, and thus the cardiac action of aldosterone alone remains to be fully clarified. The present study was undertaken to investigate the direct cardiac action of aldosterone infusion alone in rats not subjected to salt loading and uninephrectomy. Aldosterone (0.75 μg/h) was… CONTINUE READING