Exceptionally long‐term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

@article{Schmeiser2014ExceptionallyLP,
  title={Exceptionally long‐term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy},
  author={H. Schmeiser and J. Nortier and R. Singh and G. Gamboa da Costa and J. Sennesael and E. Cassuto-Viguier and D. Ambrosetti and S. Rorive and A. Pozdzik and D. Phillips and M. Stiborov{\'a} and V. Arlt},
  journal={International Journal of Cancer},
  year={2014},
  volume={135}
}
Aristolochic acid (AA) causes aristolochic acid nephropathy (AAN), first described in women in Belgium accidently prescribed Aristolochia fangchi in a slimming treatment, and also Balkan endemic nephropathy (BEN), through probable dietary contamination with Aristolochia clematitis seeds. Both nephropathies have a high risk of urothelial cancer, with AA being the causative agent. In tissues of AAN and BEN patients, a distinct DNA adduct, 7‐(deoxyadenosin‐N6‐yl)‐aristolactam I (dA‐AAI), has been… Expand
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