Exceptional resistance of human H2 glioblastoma cells to complement-mediated killing by expression and utilization of factor H and factor H-like protein 1.

@article{Junnikkala2000ExceptionalRO,
  title={Exceptional resistance of human H2 glioblastoma cells to complement-mediated killing by expression and utilization of factor H and factor H-like protein 1.},
  author={Sami Junnikkala and T Sakari Jokiranta and Manuel A Friese and Hanna Jarva and Peter F Zipfel and Seppo Meri},
  journal={Journal of immunology},
  year={2000},
  volume={164 11},
  pages={6075-81}
}
Of over 20 nucleated cell lines we have examined to date, human H2 glioblastoma cells have turned out to be the most resistant to complement-mediated cytolysis in vitro. H2 cells expressed strongly the membrane attack complex inhibitor protectin (CD59), moderately CD46 (membrane cofactor protein) and CD55 (decay-accelerating factor), but no CD35 (complement receptor 1). When treated with a polyclonal anti-H2 Ab, anti-CD59 mAb, and normal human serum, only 5% of H2 cells became killed. Under the… CONTINUE READING

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