Exceeding the limits of liver histology markers.

  title={Exceeding the limits of liver histology markers.},
  author={Shruti H Mehta and Bryan Lau and Nezam H. Afdhal and David L Thomas},
  journal={Journal of hepatology},
  volume={50 1},
BACKGROUND/AIMS Alternatives to liver biopsy for staging liver disease caused by hepatitis C virus (HCV) have not appeared accurate enough for widespread clinical use. We characterized the magnitude of the impact of error in the "gold standard" on the observed diagnostic accuracy of surrogate markers. METHODS We calculated the area under the receiver operating characteristic curve (AUROC) for a surrogate marker against the gold standard (biopsy) for a range of possible performances of each… CONTINUE READING


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The HAS recommendations for the management of the chronic hepatitis C using non-invasive biomarkers, <http://www.has-sante.fr/portail/display.jsp?id=

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