Exaptive origins of regulated mRNA decay in eukaryotes

  title={Exaptive origins of regulated mRNA decay in eukaryotes},
  author={Fursham M. Hamid and Eugene V Makeyev},
  booktitle={BioEssays : news and reviews in molecular, cellular and developmental biology},
Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense-mediated decay (NMD) and motif-specific transcript destabilization by CCCH-type zinc finger RNA-binding proteins, originated as a part of cellular defense against RNA pathogens. These branches of the mRNA turnover pathway might have been used by… CONTINUE READING
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