Examining the statistical properties of fine-scale mapping in large-scale association studies.

@article{Wiltshire2008ExaminingTS,
  title={Examining the statistical properties of fine-scale mapping in large-scale association studies.},
  author={Steven Wiltshire and Andrew P. Morris and Eleftheria Zeggini},
  journal={Genetic epidemiology},
  year={2008},
  volume={32 3},
  pages={
          204-14
        }
}
Interpretation of dense single nucleotide polymorphism (SNP) follow-up of genome-wide association or linkage scan signals can be facilitated by establishing expectation for the behaviour of primary mapping signals upon fine-mapping, under both null and alternative hypotheses. We examined the inferences that can be made regarding the posterior probability of a real genetic effect and considered different disease-mapping strategies and prior probabilities of association. We investigated the… CONTINUE READING
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