Examining the spatio-temporal expression of mRNA encoding the membrane-bound progesterone receptor-alpha isoform in human cervix and myometrium during pregnancy and labour.

@article{Chapman2006ExaminingTS,
  title={Examining the spatio-temporal expression of mRNA encoding the membrane-bound progesterone receptor-alpha isoform in human cervix and myometrium during pregnancy and labour.},
  author={Neil Chapman and Mairead Mary Kennelly and Kelly A. Harper and G. NICHOLAS EUROPE-FINNER and Stephen C. Robson},
  journal={Molecular human reproduction},
  year={2006},
  volume={12 1},
  pages={19-24}
}
Human parturition is associated with a modification in the sensitivity of the myometrium to progesterone. The molecular basis for this change, however, remains unclear. It is well documented that progesterone can exert its effects through non-genomic mechanisms, including acting through membrane-bound progesterone receptors (mPRs). Recently, a novel membrane-bound PR, termed mPRalpha, was cloned. mPRalpha was unlike any other PR in the databases, but it was seen to have significant homology to… CONTINUE READING

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