Examining the spatio-temporal expression of mRNA encoding the membrane-bound progesterone receptor-alpha isoform in human cervix and myometrium during pregnancy and labour.

@article{Chapman2006ExaminingTS,
  title={Examining the spatio-temporal expression of mRNA encoding the membrane-bound progesterone receptor-alpha isoform in human cervix and myometrium during pregnancy and labour.},
  author={N. Chapman and M. Kennelly and Kelly A. Harper and G. Europe-Finner and S. Robson},
  journal={Molecular human reproduction},
  year={2006},
  volume={12 1},
  pages={
          19-24
        }
}
  • N. Chapman, M. Kennelly, +2 authors S. Robson
  • Published 2006
  • Medicine, Biology
  • Molecular human reproduction
  • Human parturition is associated with a modification in the sensitivity of the myometrium to progesterone. The molecular basis for this change, however, remains unclear. It is well documented that progesterone can exert its effects through non-genomic mechanisms, including acting through membrane-bound progesterone receptors (mPRs). Recently, a novel membrane-bound PR, termed mPRalpha, was cloned. mPRalpha was unlike any other PR in the databases, but it was seen to have significant homology to… CONTINUE READING
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