Examining the role of actin-plasma membrane association in Pseudomonas aeruginosa infection and type III secretion translocation in migratory T24 epithelial cells.

@article{Bridge2012ExaminingTR,
  title={Examining the role of actin-plasma membrane association in Pseudomonas aeruginosa infection and type III secretion translocation in migratory T24 epithelial cells.},
  author={Dacie R Bridge and Karen H. Martin and Elizabeth R. Moore and Wendy M Lee and James A. Carroll and Claudia L. Rocha and Joan C. Olson},
  journal={Infection and immunity},
  year={2012},
  volume={80 9},
  pages={3049-64}
}
The opportunistic pathogen Pseudomonas aeruginosa targets wounded epithelial barriers, but the cellular alteration that increases susceptibility to P. aeruginosa infection remains unclear. This study examined how cell migration contributes to the establishment of P. aeruginosa infections using (i) highly migratory T24 epithelial cells as a cell culture model, (ii) mutations in the type III secretion (T3S) effector ExoS to manipulate P. aeruginosa infection, and (iii) high-resolution… CONTINUE READING