Examining the interaction of apo E and neurotoxicity on a murine model of ALS-PDC.

  title={Examining the interaction of apo E and neurotoxicity on a murine model of ALS-PDC.},
  author={J M B Wilson and Michael S. Petrik and Mohammed Hassan Moghadasian and Christopher A. Shaw},
  journal={Canadian journal of physiology and pharmacology},
  volume={83 2},
Epidemiological studies have shown a positive relationship between cycad flour consumption and the development of the neurodegenerative disorder, amyotrophic lateral sclerosis - parkinsonism - dementia complex (ALS-PDC). Apolipoprotein E (apo E) allele variations have been associated with genetic susceptibility in neurodegenerative diseases, including ALS-PDC. We have studied cycad toxicity in a mouse model of ALS-PDC with a particular interest in its impact on the central nervous system (CNS… CONTINUE READING
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