Examining the effects of the binding of the carcinogen 4-nitroquinoline-1-oxide to DNA phiX174 on DNA structure using Mung Bean nuclease and Topoisomerase I assays

  • Elizabeth Tinoco
  • Published 2017
Optical titration studies, NMR studies and studies with DNA oligonucleotides have suggested that the carcinogen 4-nitroquinoline-1-oxide binds to DNA with marked sequence selectivity and cooperativity and that its binding affects the reactivity of enzymes with DNA. The observed cooperativity and enzyme effects suggest that the binding alters DNA structure… CONTINUE READING