Examining the Essence of Migraine—Is it the Blood Vessel or the Brain? A Debate

@article{Dodick2008ExaminingTE,
  title={Examining the Essence of Migraine—Is it the Blood Vessel or the Brain? A Debate},
  author={David W. Dodick},
  journal={Headache: The Journal of Head and Face Pain},
  year={2008},
  volume={48}
}
  • D. Dodick
  • Published 1 April 2008
  • Medicine
  • Headache: The Journal of Head and Face Pain
A debate is presented that examines whether it is the blood vessel or the brain that determines the essence of migraine. 

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References

SHOWING 1-10 OF 36 REFERENCES
The neuronal versus vascular hypothesis of migraine and cortical spreading depression.
TLDR
Recent data demonstrate that neuronal excitation modulates both the pial and meningeal circulation through a critical interaction with the trigeminal nerve, supporting the concept that the integration of neuronal and vascular information in the trigeminovascular network represents a key event in the aetiology of migraine. Expand
Migraine Is Associated With Livedo Reticularis: A Prospective Study
TLDR
The relationship of livedo reticularis, an ischemic dermatopathy, and migraine, anIschemic stroke risk factor, is investigated to investigate the relationship between the two. Expand
Effect of serotonin in migraine patients
TLDR
Altering in tone, lumen, and pain threshold of the arteries alone cannot explain the complex symptomatology of the migraine attack. Expand
Cortical spreading depression--better understanding and more questions. Focus on "distinct vascular conduction with cortical spreading depression".
  • P. Goadsby
  • Psychology, Medicine
  • Journal of neurophysiology
  • 2007
TLDR
A provocative, carefully conducted series of studies that challenge a very tightly held belief about cortical spreading depression showing propagation of the dilation of cortical surface arterioles at a given time point are presented. Expand
Migraine and the risk of cervical artery dissection: A case-control study
TLDR
The association between migraine and cervical artery dissection and the hypothesis that an underlying arterial wall disease could be a predisposing condition for migraine was explored in a hospital-based case-control study. Expand
Arterenol (norepinephrine) and vascular headache of the migraine type; studies on headache.
TLDR
The potency of arterenol (norepinephrine) as a vasoconstrictor suggested that it might affect the intensity and duration of the pain and further elucidate the mechanism of vascular headache. Expand
Changes in regional cerebral blood flow during the course of classic migraine attacks
TLDR
Regional cerebral blood flow following carotid arteriography was studied in thirteen patients with classic migraine and suggested that focal symptoms and blood flow changes may be secondary to spreading depression of Leao. Expand
Brief report: bilateral spreading cerebral hypoperfusion during spontaneous migraine headache.
TLDR
A series of patients who had migraine headaches during serial cerebral blood-flow measurement by the intracarotid xenon-133 technique observed a pattern of localized decreases in flow that appeared to spread contiguously along the cerebral cortex. Expand
Focal headache during balloon inflation in the internal carotid and middle cerebral arteries.
TLDR
18 patients who underwent balloon inflation in the distal internal carotid artery and middle cerebral artery stem during embolization therapy for intracerebral arteriovenous malformations have reproducible patterns of headache during balloon inflation. Expand
Migraine and MTHFR C677T genotype in a population‐based sample
TLDR
This data indicates that the MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. Expand
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