Examining glucose transport in single vascular smooth muscle cells with a fluorescent glucose analog.

@article{Lloyd1999ExaminingGT,
  title={Examining glucose transport in single vascular smooth muscle cells with a fluorescent glucose analog.},
  author={Pamela G. Lloyd and Christopher D. Hardin and Michael S Sturek},
  journal={Physiological research},
  year={1999},
  volume={48 6},
  pages={401-10}
}
Changes in vascular smooth muscle glucose transport are thought to contribute to the pathogenesis of vascular disease in conditions such as diabetes, yet no single-cell assay for glucose uptake by VSM exists. Therefore, we examined the uptake of the fluorescent glucose analog 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxyglucose (2-NBDG) in isolated pig vascular smooth muscle cells (VSMC) using digital imaging microscopy. Uptake of 2-NBDG by VSMC was inhibited by D-glucose but not by L… CONTINUE READING

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