Examining basal chloride transport using the nasal potential difference response in a murine model.

@article{Brady2001ExaminingBC,
  title={Examining basal chloride transport using the nasal potential difference response in a murine model.},
  author={Kristine G Brady and Thomas Kelley and Mitchell L. Drumm},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 5},
  pages={L1173-9}
}
Epithelia of humans and mice with cystic fibrosis are unable to secrete chloride in response to a chloride gradient or to cAMP-elevating agents. Bioelectrical properties measured using the nasal transepithelial potential difference (TEPD) assay are believed to reflect these cystic fibrosis transmembrane conductance regulator (CFTR)-dependent chloride transport defects. Although the response to forskolin is CFTR mediated, the mechanisms responsible for the response to a chloride gradient are… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Similar Papers

Loading similar papers…