Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer

@inproceedings{Cathcart2010ExaminationOT,
  title={Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer},
  author={Mary-Clare Cathcart and Kathy Gately and Robert Cummins and Elaine W. Kay and Kenneth J O'byrne and Graham P. Pidgeon},
  booktitle={Molecular Cancer},
  year={2010}
}
Thromboxane synthase (TXS) metabolises prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS over-expression has been reported in a range of cancers, and associated with a poor prognosis. TXS inhibition induces cell death in-vitro, providing a rationale for therapeutic intervention. We aimed to determine the expression profile of TXS in NSCLC and if it is prognostic and/or a survival factor in the disease. TXS expression was examined in human NSCLC and matched… CONTINUE READING
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