Examination of the SigC regulon and cobalamin biosynthesis in Mycobacterium tuberculosis

@inproceedings{GrosseSiestrup2012ExaminationOT,
  title={Examination of the SigC regulon and cobalamin biosynthesis in Mycobacterium tuberculosis},
  author={Benjamin Tobias Grosse-Siestrup},
  year={2012}
}
The causative agent of tuberculosis (TB), Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality, claiming ~2 million lives annually. The current live-attenuated vaccine protects against meningeal TB in children, but protection against pulmonary TB varies from 0-80% among post-adolescents. Understanding the mechanisms by which M. tuberculosis adapts to successfully reside and cause disease in the host is vital for rational design of therapeutics, vaccines, and… CONTINUE READING

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