Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans

@article{Yu2011ExaminationOT,
  title={Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans},
  author={Yanke Yu and Suzanna Maria Zick and Xiaoqin Li and Peng Zou and Benjamin J. Wright and D. -Y. Sun},
  journal={The AAPS Journal},
  year={2011},
  volume={13},
  pages={417-426}
}
Ginger extracts have been studied in various clinical trials for different indications. However, the pharmacokinetics of the ginger active constituents in human biological matrices is not well investigated. This study aims to develop a LC-MS/MS method for simultaneous measurement of 6-, 8-, and 10-gingerols and 6-shogaol and study their pharmacokinetics in human plasma and colon tissues. A sensitive LC-MS/MS method was established and validated with a low limit of quantification of 2–5 ng/mL… CONTINUE READING
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