Examination of stress-related genes in human temporal versus occipital cortex in the course of neurodegeneration: involvement of 14-3-3 zeta in this dynamic process.

@article{Souli2004ExaminationOS,
  title={Examination of stress-related genes in human temporal versus occipital cortex in the course of neurodegeneration: involvement of 14-3-3 zeta in this dynamic process.},
  author={Cathia Souli{\'e} and Annie Nicole and Andr{\'e} Delacourte and Ir{\`e}ne Ceballos-Picot},
  journal={Neuroscience letters},
  year={2004},
  volume={365 1},
  pages={1-5}
}
The progressive invasion of the brain by neurofibrillary tangles characterized by paired helical filaments (PHF) along a precise network is stereotypical and hierarchical from normal aging to severe Alzheimer's disease. We describe here the differential expression of genes in the temporal area with PHF compared with the occipital area non-affected by PHF in cases with cognitive impairment versus the same cortical regions of control human brains without PHF. A stronger overexpression for 14-3-3… CONTINUE READING