Examination of reproductive aging milestones among women who carry the FMR1 premutation.

  title={Examination of reproductive aging milestones among women who carry the FMR1 premutation.},
  author={Emily Graves Allen and Amy K. Sullivan and Michele Marcus and C. Small and Carmen Dom{\'i}nguez and Michael P Epstein and Krista H Charen and Weiya He and Kira C. Taylor and Stephanie L. Sherman},
  journal={Human reproduction},
  volume={22 8},
BACKGROUND The fragile X premutation is characterized by a large CGG repeat track (55-199 repeats) in the 5' UTR of the FMR1 gene. This X-linked mutation leads to an increased risk for premature ovarian failure; interestingly, the association of repeat size with risk is non-linear. We hypothesize that the premutation-associated ovarian insufficiency is due to a diminished oocyte pool and examined reproductive aging milestones by repeat size group to determine if the same non-linear association… CONTINUE READING
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FMR1 premutation: a leading cause of inherited ovarian dysfunction

  • SL Sherman, K Taylor, EG. Allen
  • Nova Science Publishers,
  • 2007
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