Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

@article{House1990ExaminationOI,
  title={Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.},
  author={Robert V. House and Lloyd D. Lauer and Michael J Murray and Philip T. Thomas and J P Ehrlich and Gary R Burleson and Jack H. Dean},
  journal={Journal of toxicology and environmental health},
  year={1990},
  volume={31 3},
  pages={203-15}
}
Adult female B6C3F1 mice were given a single ip dose of 0, 01, 1.0, or 10.0 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and examined for immune function and host resistance 7-10 d later. Exposure to TCDD resulted in a significant dose-related decrease in induction of both IgM and IgG antibody-forming cells. This suppression was noted for both T-dependent and T-independent antigens. TCDD at a dosage of 10 micrograms/kg was shown to suppress production of antibody to viral… CONTINUE READING

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