Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice.

@article{Fugger2001ExaminationOE,
  title={Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice.},
  author={Heather N. Fugger and Ashok Kumar and Dennis B. Lubahn and Kenneth S. Korach and Thomas C. Foster},
  journal={Neuroscience letters},
  year={2001},
  volume={309 3},
  pages={207-9}
}
Hippocampal slices from rats exhibit a rapid increase in basal synaptic transmission following 17 beta-estradiol (E(2)) application. In the current study we examined the role of the classic genomic receptor, estrogen receptor alpha (ER alpha), in mediating E(2) effects on synaptic transmission. E(2) (100 pM) increased the extracellular synaptic response in hippocampal slices from gonadectomized male and female mice lacking a functional ER alpha knockout (ER alpha KO) and wild-type (WT… CONTINUE READING