Examination of assumptions for local cerebral blood flow studies in PET.

  title={Examination of assumptions for local cerebral blood flow studies in PET.},
  author={Robert A. Koeppe and G D Hutchins and Jill M. Rothley and Richard D. Hichwa},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={28 11},
Two common assumptions made in most positron emission tomography (PET) cerebral blood flow techniques have been examined in detail. These are (1) that the blood-borne radioactivity component in the measured PET data is negligible, and (2) that differences in arrival time of the arterial bolus across the brain cause insignificant biases in the estimated cerebral blood flow (CBF) values. Biases in CBF values due to partial failure of these assumptions have been predicted by computer simulation… CONTINUE READING
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