Examination of alpha-carbonyl derivatives of nitrosodimethylamine and ethylnitrosomethylamine as putative proximate carcinogens.

@article{Elespuru1993ExaminationOA,
  title={Examination of alpha-carbonyl derivatives of nitrosodimethylamine and ethylnitrosomethylamine as putative proximate carcinogens.},
  author={Rosalie K Elespuru and Joseph E. Saavedra and Robert M. Kovatch and William Lijinsky},
  journal={Carcinogenesis},
  year={1993},
  volume={14 6},
  pages={1189-93}
}
Metabolites produced by enzymic oxidation are believed to be responsible for the mutagenicity and carcinogenicity of N-nitrosamines. Although alpha-hydroxy compounds are often considered, a related and more stable oxidation product, the alpha-carbonyl compound, was studied here. The alpha-carbonyl derivatives of nitrosodimethylamine (NDMA) and ethylnitrosomethylamine (oxidized at either the methyl or the ethyl group) were synthesized. The derivatives were methylnitrosoformamide (MNFA… CONTINUE READING