Examination of GABAergic and dopaminergic compounds in the acquisition of nicotine-conditioned hyperactivity in rats.

@article{Palmatier2002ExaminationOG,
  title={Examination of GABAergic and dopaminergic compounds in the acquisition of nicotine-conditioned hyperactivity in rats.},
  author={Matthew I. Palmatier and Rick A Bevins},
  journal={Neuropsychobiology},
  year={2002},
  volume={45 2},
  pages={
          87-94
        }
}
In rats, a distinct environment repeatedly paired with nicotine (0.421 mg/kg base, s.c.) comes to evoke an increase in activity in the absence of any drug. This hyperactivity indicates a Pavlovian-conditioned association between the environment and nicotine. We investigated whether a dopamine D(1) receptor antagonist (SCH-23390), a D(2)/D(3) antagonist (eticlopride) or a GABA(B) agonist (baclofen) would prevent the acquisition of nicotine-conditioned hyperactivity. In saline-pretreated rats… CONTINUE READING
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