Exaggerated tubuloglomerular feedback activity in genetic hypertension is mediated by ANG II and AT1 receptors.

@article{Brnnstrm1996ExaggeratedTF,
  title={Exaggerated tubuloglomerular feedback activity in genetic hypertension is mediated by ANG II and AT1 receptors.},
  author={Kristina Br{\"a}nnstr{\"o}m and Peter Morsing and William J. Arendshorst},
  journal={The American journal of physiology},
  year={1996},
  volume={270 5 Pt 2},
  pages={F749-55}
}
The purpose of the present study was to determine the role of endogenous angiotensin II in exaggerated tubuloglomerular feedback (TGF) in young euvolemic spontaneously hypertensive rats (SHR). TGF was characterized by measuring proximal tubular stop-flow pressure (Psf) responses to loop of Henle perfusion before and during losartan infusion in 7-wk-old SHR and Wistar-Kyoto rats (WKY). In the control period, TGF responses were exaggerated in SHR compared with WKY. This was evidenced by a larger… CONTINUE READING

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