Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure.

@article{Shaltout2011ExaggeratedSM,
  title={Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure.},
  author={Hossam A. Shaltout and Mark C. Chappell and J Cameron Rose and Debra I. Diz},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 6},
  pages={E979-85}
}
Glucocorticoid administration to women at risk for preterm delivery is standard practice to enhance neonatal survival. However, antenatal betamethasone exposure (β-exposure) increases mean arterial pressure (MAP) in adult sheep (1.8 yr old) and results in impaired baroreflex sensitivity (BRS) for control of heart rate (HR). In the current studies we tested the hypothesis that enhanced sympathetic nervous system and hypothalamo-pituitary-adrenal (HPA) axis-mediated responses are evident at an… CONTINUE READING
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