Exaggerated proinflammatory and Th1 responses in the absence of gamma/delta T cells after infection with Listeria monocytogenes.

@article{Skeen2001ExaggeratedPA,
  title={Exaggerated proinflammatory and Th1 responses in the absence of gamma/delta T cells after infection with Listeria monocytogenes.},
  author={Marianne J. Skeen and Emily Parker Rix and Molly M. Freeman and Hans K. Ziegler},
  journal={Infection and immunity},
  year={2001},
  volume={69 12},
  pages={
          7213-23
        }
}
While gamma/delta T cells are involved in host defense and immunopathology in a variety of infectious diseases, their precise role is not yet clearly defined. In the absence of gamma/delta T cells, mice die after infection with a dose of Listeria monocytogenes that is not lethal in immunologically intact animals. Morbidity might result from insufficient levels of cytokines normally produced by gamma/delta T cells or conversely from an excess of cytokines due to a lack of down-regulation of the… CONTINUE READING
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