Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

  title={Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice},
  author={Fangfang Yin and Rebecca Banerjee and Bobby Thomas and Ping Zhou and Liping Qian and Ting Jia and Xiaojing Ma and Yao Ma and C Iadecola and Myron Flint Beal and Carl Nathan and Aihao Ding},
  booktitle={The Journal of experimental medicine},
Progranulin (PGRN) is a widely expressed protein involved in diverse biological processes. Haploinsufficiency of PGRN in the human causes tau-negative, ubiquitin-positive frontotemporal dementia (FTD). However, the mechanisms are unknown. To explore the role of PGRN in vivo, we generated PGRN-deficient mice. Macrophages from these mice released less interleukin-10 and more inflammatory cytokines than wild type (WT) when exposed to bacterial lipopolysaccharide. PGRN-deficient mice failed to… CONTINUE READING
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