Exaggerated cation leak from oxygenated sickle red blood cells during deformation: evidence for a unique leak pathway.

@article{Sugihara1992ExaggeratedCL,
  title={Exaggerated cation leak from oxygenated sickle red blood cells during deformation: evidence for a unique leak pathway.},
  author={Takashi Sugihara and Robert P. Hebbel},
  journal={Blood},
  year={1992},
  volume={80 9},
  pages={2374-8}
}
An abnormal susceptibility of the sickle red blood cell (RBC) membrane to deformation could compromise its permeability barrier function and contribute to the exuberant cation leakiness occurring during the sickling phenomenon. We examined this hypothesis by subjecting RBCs at ambient oxygen tension to elliptical deformation, applying shear stress in a… CONTINUE READING