Exaggerated TSH response to TRH ("sub-biochemical" hypothyroidism) in prepubertal and adolescent thalassaemic patients with iron overload: prevalence and 20-year natural history.

@article{Sanctis2008ExaggeratedTR,
  title={Exaggerated TSH response to TRH ("sub-biochemical" hypothyroidism) in prepubertal and adolescent thalassaemic patients with iron overload: prevalence and 20-year natural history.},
  author={Vincenzo De Sanctis and Rita Tanas and Maria Rita Gamberini and Monica Sprocati and Maria Rita Govoni and Maria Marsella},
  journal={Pediatric endocrinology reviews : PER},
  year={2008},
  volume={6 Suppl 1},
  pages={170-3}
}
The severity of thyroid dysfunction in patients with beta-thalassaemia major is variable in different series. An exaggerated thyrotropin response to thyrotropin-releasing-hormone (TRH) has been found in 1 out of 5 beta-thalassaemia major patients. Because it is not well known how many of these patients will develop overt or subclinical hypothyroidism, we reviewed retrospectively the thyroid status (thyroid hormones, TBG, TG basal and TSH peak after TRH test) of 24 children and adolescents with… CONTINUE READING