Exactly linearizing adaptive control of propofol and remifentanil using a reduced Wiener model for the depth of anesthesia


A closed-loop adaptive controller for propofol and remifentanil administration using BIS measurements is proposed in this paper. The controller design relies on a reduced MISO Wiener model for the depth of anesthesia. The exact linearization of this minimal Wiener structure using the model continuous-time parameter estimates calculated online by an extended… (More)
DOI: 10.1109/CDC.2012.6425924

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