Exact reconstruction of gene regulatory networks using compressive sensing

  title={Exact reconstruction of gene regulatory networks using compressive sensing},
  author={Young Hwan Chang and Joe W. Gray and Claire J. Tomlin},
  booktitle={BMC Bioinformatics},
We consider the problem of reconstructing a gene regulatory network structure from limited time series gene expression data, without any a priori knowledge of connectivity. We assume that the network is sparse, meaning the connectivity among genes is much less than full connectivity. We develop a method for network reconstruction based on compressive sensing, which takes advantage of the network’s sparseness. For the case in which all genes are accessible for measurement, and there is no… CONTINUE READING
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Momentbased inference predicts bimodality in transient gene expression

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  • Proceedings of the National Academy of Science of…
  • 2012
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