Exact model reduction of combinatorial reaction networks

Abstract

Receptors and scaffold proteins usually possess a high number of distinct binding domains inducing the formation of large multiprotein signaling complexes. Due to combinatorial reasons the number of distinguishable species grows exponentially with the number of binding domains and can easily reach several millions. Even by including only a limited number of… (More)
DOI: 10.1186/1752-0509-2-78

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