Exacerbation or Unmasking of Focal Neurologic Deficits by Sedatives

@article{Thal1996ExacerbationOU,
  title={Exacerbation or Unmasking of Focal Neurologic Deficits by Sedatives},
  author={Gary Thal and Michele D. Szabo and Maria V. Lopez-Bresnahan and Gregory J. Crosby},
  journal={Anesthesiology},
  year={1996},
  volume={85},
  pages={21-25}
}
Background Transient focal neurologic deficits have been observed in patients emerging from brain tumor or carotid surgery, and a pharmacologic effect of anesthetic agents has been proposed as the cause of such neurologic dysfunction. Therefore, the effect of sedation with midazolam or fentanyl on motor neurologic function was studied prospectively and preoperatively in patients with carotid disease or mass lesions of the brain. Methods Fifty-four unpremedicated adult patients with carotid… 

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Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas.

In patients with eloquent area gliomas, mild sedation with midazolam induced motor coordination deficits in upper limbs that were almost completely reversed by the benzodiazepine antagonist flumazenil, suggesting that this is a reversible abnormality linked to occupation of the receptor by midAZolam.

A controlled prospective study of neuropsychological dysfunction following carotid endarterectomy.

Examination of neuropsychological test performance in patients following carotid endarterectomy vs a control group of patients older than 60 years following spine surgery found subtle cognitive decline following CEA occurs and persists for at least several weeks after surgery.

Recovery and neurological evaluation.

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