Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA.

@article{Tsunoda1999ExacerbationOV,
  title={Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA.},
  author={Ikuo Tsunoda and Neal D. Tolley and Diethilde J. Theil and J. Lindsay Whitton and Hitomi Kobayashi and Robert Shin Fujinami},
  journal={Brain pathology},
  year={1999},
  volume={9 3},
  pages={481-93}
}
Theiler's murine encephalomyelitis virus (TMEV) infection and relapsing-remitting experimental allergic encephalomyelitis (R-EAE) have been used to investigate the viral and autoimmune etiology of multiple sclerosis (MS), a possible Th1-type mediated disease. DNA immunization is a novel vaccination strategy in which few harmful effects have been reported. Bacterial DNA and oligodeoxynucleotides, which contain CpG motifs, have been reported to enhance immunostimulation. Our objectives were two… CONTINUE READING

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