Exacerbation of ulcerative colitis after rituximab salvage therapy.

@article{Goetz2007ExacerbationOU,
  title={Exacerbation of ulcerative colitis after rituximab salvage therapy.},
  author={Martin Goetz and Raja Atreya and Maryam Ghalibafian and Peter R. Galle and Markus Friedrich Neurath},
  journal={Inflammatory bowel diseases},
  year={2007},
  volume={13 11},
  pages={
          1365-8
        }
}
BACKGROUND B-cells are considered to play a pathogenic role in human ulcerative colitis (UC) by producing autoantibodies that cause epithelial cell damage. Here we report on a patient with intractable UC who suffered from a severe exacerbation of UC after salvage therapy with rituximab, a B-cell-depleting anti-CD20-antibody. METHODS A 58-year-old patient with active long-standing UC and unresponsiveness or adverse events to mesalamine, corticosteroids, azathioprine, methotrexate, infliximab… CONTINUE READING
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