Exacerbation of seizures in medial temporal lobe epilepsy due to an alpha1-adrenergic antagonist.

PURPOSE We describe the first reported case of a proconvulsant effect of an alpha(1)-adrenergic antagonist in humans. METHODS A patient with medial temporal lobe seizures (MTLE) had increased seizure frequency after treatment with tamsulosin, an alpha(1)-adrenergic antagonist. RESULTS Experimental evidence suggests that noradrenaline, which has… (More)