Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses.

@article{Herz2014ExacerbationOI,
  title={Exacerbation of ischemic brain injury in hypercholesterolemic mice is associated with pronounced changes in peripheral and cerebral immune responses.},
  author={Josephine Herz and Sabine I Hagen and Eileen Bergm{\"u}ller and Pascal Sabellek and Joachim R G{\"o}thert and Jan Buer and Wiebke Hansen and Dirk Matthias Hermann and Thorsten R Doeppner},
  journal={Neurobiology of disease},
  year={2014},
  volume={62},
  pages={456-68}
}
Inflammation contributes to ischemic brain injury. However, translation of experimental findings from animal models into clinical trials is still ineffective, since the majority of human stroke studies mainly focus on acute neuroprotection, thereby neglecting inflammatory mechanisms and inflammation-associated co-morbidity factors such as hypercholesterolemia. Therefore, both wildtype and ApoE(-/-) mice that exhibit increased serum plasma cholesterol levels fed with normal or high cholesterol… CONTINUE READING