Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic KK-A(y) mice.

@article{Okumura2006ExacerbationOD,
  title={Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic KK-A(y) mice.},
  author={Kyoko Okumura and Kenichi Ikejima and Kazuyoshi Kon and Wataru Abe and Shunhei Yamashina and Nobuyuki Enomoto and Yoshiyuki Takei and Nobuhiro Sato},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2006},
  volume={36 3},
  pages={217-28}
}
In this study, we investigated a dietary model of steatohepatitis caused by methionine- and choline-deficiency (MCD) in obese, diabetic KK-A(y) mice. Male KK-A(y) mice and C57Bl/6 mice were fed an MCD diet for up to 8 weeks, and liver pathology was evaluated. Hepatic steatosis and inflammatory infiltration were more prominent in KK-A(y) mice than in C57Bl/6 mice 4 weeks after feeding with MCD diet. MCD diet-induced increases in tumor necrosis factor (TNF)-alpha mRNA levels, as well as lipid… CONTINUE READING

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