Exacerbation of diabetes by excess insulin action.

@article{Somogyi1959ExacerbationOD,
  title={Exacerbation of diabetes by excess insulin action.},
  author={Michael Somogyi},
  journal={The American journal of medicine},
  year={1959},
  volume={26 2},
  pages={
          169-91
        }
}
  • M. Somogyi
  • Published 1959
  • Medicine
  • The American journal of medicine
Abstract 1.1. Detailed laboratory data gathered on severe diabetic subjects, in closely controlled observations and experiments, show complete lack of parallelism between the amount of insulin injected and the amount of carbohydrates utilized; even when both diet and insulin dosage are kept constant, glycosuria varies over wide ranges and the blood sugar oscillates between very low and very high levels. 2.2. The laboratory records of patients who are treated with substantial doses of insulin… Expand
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References

SHOWING 1-10 OF 32 REFERENCES
Changes in ketonemia and ketonuria
  • action. Am. J. Med
  • 1959
Diabetogenic effect of hyperinsulinism.
  • M. Somogyi
  • Medicine
  • The American journal of medicine
  • 1959
TLDR
Evidence is presented showing that the greater the excess of insulin and the longer a subject is exposed to its adverse effect, the greater is the diabetogenic effect of the treatment. Expand
J. Med
  • J. Med
  • 1959
Oberdisse and Priv.-Doz
  • partly colored illustrations,
  • 1959
Quantitative relationship between insulin dosage and amount of carbohydrates utilized in diabetic persons.
STIMATION of the insulin requirement of diabetic patients has to this day remained a purely empirical procedure, with the goal to eliminate glycosuria and restore normal blood sugar levels. WhenExpand
Hypo - adrenal function and adrenalectomy in human
  • diabetes
  • 1956
Unstable Diabetes: Panel Discussion
TLDR
Those patients who present a problem for all of us in everyday practice, namely those with unstable diabetes are discussed, which have a good chance of living as long as, or even longer in many instances, with their diabetes than they might be expected to live without it. Expand
...
1
2
3
4
...