Exacerbation of alcoholic liver injury by enteral endotoxin in rats.

@article{Mathurin2000ExacerbationOA,
  title={Exacerbation of alcoholic liver injury by enteral endotoxin in rats.},
  author={Philippe Mathurin and Qiang Deng and Ali Keshavarzian and Sharda Sharma Choudhary and Earle W. Holmes and Hidekazu Tsukamoto},
  journal={Hepatology},
  year={2000},
  volume={32 5},
  pages={
          1008-17
        }
}
Increased gut permeability (leaky gut) and endotoxin-mediated Kupffer cell activation are proposed as the mechanisms of alcoholic liver injury. Although ethanol feeding is shown to sensitize the liver for injury induced by parental administration of lipopolysaccharide (LPS), how enteral LPS loading affects alcoholic liver injury is yet to be tested. The present study provides direct evidence for enhanced entrance to portal circulation of LPS enterally administered to the intragastric ethanol… CONTINUE READING
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