Exacerbation of Psoriasis during Lithium Treatment

  title={Exacerbation of Psoriasis during Lithium Treatment},
  author={T. Sasaki and Sumi Saito and Michiko Aihara and Junko Ohsawa and Zenro Ikezawa},
  journal={The Journal of Dermatology},
Exacerbation of psoriasis was observed in a 28‐year‐old patient following the addition of lithium carbonate to a treatment regimen of carbamazepine and other drugs for ***manic‐depressive psychosis. The biopsied lesion histologically showed a typical psoriasiform tissue reaction and immunohistochemically, remarkable infiltration of activated helper T cells. Immunologic reaction to lithium in a patch test and a lymphocyte proliferation test could not be demonstrated. The mechanisms of lithium… 

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