Exacerbated signs of an immunosuppressive AIDS-like disease in macaques infected with multiple retroviruses

@inproceedings{Mitchell2011ExacerbatedSO,
  title={Exacerbated signs of an immunosuppressive AIDS-like disease in macaques infected with multiple retroviruses},
  author={Jane L Mitchell and Simon Hood and Ghazi Auda and Neil M. Almond and Nicola J. Rose},
  booktitle={Retrovirology},
  year={2011}
}
In retroviral co-infection one or more of the viruses may display altered dynamics impacting on the pathology within the host. To characterise the nature of such changes we studied cynomolgus macaques naturally infected with three retroviruses. DNA was isolated from eleven tissues from macaques infected with SFV-1 (4), SRV-2/SFV-1 (4), STLV-1/SFV-1 (3), SRV-2/STLV-1/SFV-1 (6), and one uninfected macaque. Proviral load and distribution were evaluated by quantitative PCR. Immunopathology was… CONTINUE READING