Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells

@inproceedings{Bouma2014ExacerbatedEA,
  title={Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells},
  author={Gerben Bouma and Natalie A. Carter and Mike Recher and Dessislava Malinova and Marsilio Adriani and Luigi D Notarangelo and Siobhan O. Burns and C Mauri and Adrian J. Thrasher},
  booktitle={European journal of immunology},
  year={2014}
}
Patients deficient in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) are predisposed to varied autoimmunity, suggesting it has an important controlling role in participating cells. IL-10-producing regulatory B (Breg) cells are emerging as important mediators of immunosuppressive activity. In experimental, antigen-induced arthritis WASp-deficient (WASp knockout [WAS KO]) mice developed exacerbated disease associated with decreased Breg cells and regulatory T (Treg) cells, but… CONTINUE READING

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