Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy.

@article{Montagna2001ExVP,
  title={Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy.},
  author={Daniela Montagna and Rita Maccario and Franco Locatelli and Vittorio Rosti and Yiping Yang and P L Farness and Antonia Moretta and Patrizia Comoli and Enrica Montini and Antonella Vitiello},
  journal={Blood},
  year={2001},
  volume={98 12},
  pages={3359-66}
}
Adoptive cellular immunotherapy has proven to be a successful approach in preventing and curing cytomegalovirus infection and Epstein-Barr virus-associated lymphomas after bone marrow transplantation. Translation of this approach for preventing leukemia relapse after bone marrow transplantation might require ex vivo priming and long-term maintenance of leukemia blast-specific T cells. To accomplish this goal, procedures were optimized for the in vitro priming of naive CD8 using dendritic cells… CONTINUE READING