Ex-vivo perfusion bioassay : an excellent technique to measure the bioactivity of inhalable insulin coated microcrystals

@inproceedings{Ross2002ExvivoPB,
  title={Ex-vivo perfusion bioassay : an excellent technique to measure the bioactivity of inhalable insulin coated microcrystals},
  author={Alistair C. Ross and Howard N. E. Stevens and Johann Partridge and Barry D. Moore and Mar{\'i}a Victoria Pereira Flores and Marie-Claire Parker and Amanda Brown and Christopher Hillier and Jamie J Coleman},
  year={2002}
}
Purpose: To measure the bioactivity of inhalable insulin coated microcrystals using a perfusion bioassay that measures its vasodilatory effect on smooth muscle arterial tissue. Methods: The bioactivity of an insulin protein coated microcrystal (PCMC), a potential candidate for pulmonary drug delivery and commercial insulin was determined on a Danish Myo Tech P110 pressure myograph system. 12 week old Mesenteric resistance arteries from Male Wistar rats were isolated and immersed in a… CONTINUE READING

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