Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig–coated artificial antigen-presenting cells

@article{Oelke2003ExVI,
  title={Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig–coated artificial antigen-presenting cells},
  author={Mathias Oelke and Marcela V Maus and Dominic Didiano and Carl H June and Andreas Mackensen and Jonathan P Schneck},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={619-625}
}
Adoptive immunotherapy holds promise as a treatment for cancer and infectious diseases, but its development has been impeded by the lack of reproducible methods for generating therapeutic numbers of antigen-specific CD8+ cytotoxic T lymphocytes (CTLs). As a result, there are only limited reports of expansion of antigen-specific CTLs to the levels required for clinical therapy. To address this issue, artificial antigen-presenting cells (aAPCs) were made by coupling a soluble human leukocyte… CONTINUE READING
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