Ex vivo human trabecular bone model for biocompatibility evaluation of calcium phosphate composites modified with spray dried biodegradable microspheres.

@article{Schnieders2013ExVH,
  title={Ex vivo human trabecular bone model for biocompatibility evaluation of calcium phosphate composites modified with spray dried biodegradable microspheres.},
  author={Julia Schnieders and Uwe Gbureck and Oliver Germershaus and Marita Kratz and David B. Jones and Thomas Robert Kissel},
  journal={Advanced healthcare materials},
  year={2013},
  volume={2 10},
  pages={
          1361-9
        }
}
Our aim was to study the suitability of the ex-vivo human trabecular bone bioreactor ZetOS to test the biocompatibility of calcium phosphate bone cement composites modified with spray dried, drug loaded microspheres. We hypothesized, that this bone bioreactor could be a promising alternative to in vivo assessment of biocompatibility in living human bone over a defined time period. Composites consisting of tetracycline loaded poly(lactic-co-glycolic acid) microspheres and calcium phosphate bone… CONTINUE READING
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