Ex vivo gene transfer of brain-derived neurotrophic factor to the intact rat forebrain: neurotrophic effects on cholinergic neurons.

@article{MartnezSerrano1996ExVG,
  title={Ex vivo gene transfer of brain-derived neurotrophic factor to the intact rat forebrain: neurotrophic effects on cholinergic neurons.},
  author={Alberto Mart{\'i}nez-Serrano and Petros A. Hantzopoulos and Anders Bj{\"o}rklund},
  journal={The European journal of neuroscience},
  year={1996},
  volume={8 4},
  pages={727-35}
}
Neurotrophic effects of human brain-derived neurotrophic factor (hBDNF) on forebrain cholinergic neurons were addressed after ex vivo gene transfer to the intact adult rat brain, using a conditionally immortalized neural progenitor cell line (CINP) engineered to secrete the neurotrophin (2.8 ng/h/10(6) cells). This cell line was derived by repeated… CONTINUE READING